Test Bank For Pharmacotherapeutics for Nurse Practitioner Prescribers 3rd Edition by Teri Moser Woo
Chapter 2: Review of Basic Principles of Pharmacology
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. A patient’s nutritional intake and lab work reflects hypoalbuminemia. This is critical to prescribing because:
|
A. |
Distribution of drugs to target tissue may be affected |
|
B. |
The solubility of the drug will not match the site of absorption |
|
C. |
There will be less free drug available to generate an effect |
|
D. |
Drugs bound to albumin are readily excreted by the kidney |
____ 2. Drugs that have a significant first-pass effect:
|
A. |
Must be given by the enteral (oral) route only |
|
B. |
Bypass the hepatic circulation |
|
C. |
Are rapidly metabolized by the liver and may have little if any desired action |
|
D. |
Are converted by the liver to more active and fat-soluble forms |
____ 3. The route of excretion of a volatile drug will likely be:
|
A. |
The kidneys |
|
B. |
The lungs |
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C. |
The bile and feces |
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D. |
The skin |
____ 4. Medroxyprogesterone (Depo Provera) is prescribed IM to create a storage reservoir of the drug. Storage reservoirs:
|
A. |
Assure that the drug will reach its intended target tissue |
|
B. |
Are the reason for giving loading doses |
|
C. |
Increase the length of time a drug is available and active |
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D. |
Are most common in collagen tissues |
____ 5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:
|
A. |
Propensity to go to the target receptor |
|
B. |
Biological half-life |
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C. |
Pharmacodynamics |
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D. |
Safety and side effects |
____ 6. Azithromycin dosing requires the first day’s dose be twice those of the other 4 days of the prescription. This is considered a loading dose. A loading dose:
|
A. |
Rapidly achieves drug levels in the therapeutic range |
|
B. |
Requires four to five half-lives to attain |
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C. |
Is influenced by renal function |
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D. |
Is directly related to the drug circulating to the target tissues |
____ 7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect is the:
|
A. |
Minimum adverse effect level |
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B. |
Peak of action |
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C. |
Onset of action |
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D. |
Therapeutic range |
____ 8. Phenytoin requires a trough level be drawn. Peak and trough levels are done:
|
A. |
When the drug has a wide therapeutic range |
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B. |
When the drug will be administered for a short time only |
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C. |
When there is a high correlation between the dose and saturation of receptor sites |
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D. |
To determine if a drug is in the therapeutic range |
____ 9. A laboratory result indicates the peak level for a drug is above the minimum toxic concentration. This means that the:
|
A. |
Concentration will produce therapeutic effects |
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B. |
Concentration will produce an adverse response |
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C. |
Time between doses must be shortened |
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D. |
Duration of action of the drug is too long |
____ 10. Drugs that are receptor agonists may demonstrate what property?
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A. |
Irreversible binding to the drug receptor site |
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B. |
Up-regulation with chronic use |
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C. |
Desensitization or down-regulation with continuous use |
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D. |
Inverse relationship between drug concentration and drug action |
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